Membrane fusion induced by influenza virus hemagglutinin requires protein bound fatty acids
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منابع مشابه
Membrane fusion mediated by the influenza virus hemagglutinin requires the concerted action of at least three hemagglutinin trimers
In this study we tested the hypothesis that fusion mediated by the influenza virus hemagglutinin (HA) is a cooperative event. To so this we characterized 3T3 cell lines that express HA at nine different defined surface densities. HA densities ranged from 1.0 to 12.6 x 10(3) HA trimers/microns2 as determined by quantitative fluorescent antibody binding. The lateral mobility and percent mobile fr...
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Influenza virus penetrates cells by fusion of viral and endosomal membranes catalyzed by the viral hemagglutinin (HA). Structures of the initial and final states of the HA trimer define the fusion endpoints, but do not specify intermediates. We have characterized these transitions by analyzing low-pH-induced fusion kinetics of individual virions and validated the analysis by computer simulation...
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Fusion of influenza viruses with target membranes is induced by acid and involves complex changes in the viral fusion protein hemagglutinin (HA) and in the contact sites between viruses and target membranes (Stegmann, T., White, J. M., and Helenius, A. (1990) EMBO J. 9, 4231-4241). At 0 degrees C, in a first, kinetically distinct step, target membranes irreversibly adhere to the viruses. Fusion...
متن کاملThe influenza virus hemagglutinin: a model protein in the study of membrane fusion.
2. A working model for influenza hemagglutinin fusion activity . . . . . . . . . . . . . . . . . . . . . 150 2.1. First contact: role of target membrane viral receptors in membrane merging . . . . . . . . . 150 2.2. Turning it on: low pH conformational changes in the HA structure . . . . . . . . . . . . . . . 150 2.3. Disturbing influences: insertion of the viral fusion peptide into the target ...
متن کاملStructural Insights into the Membrane Fusion Mechanism Mediated by Influenza Virus Hemagglutinin
Membrane fusion is involved in many fundamental cellular processes and entry of enveloped viruses into host cells. Influenza type A virus HA has long served as a paradigm for mechanistic studies of protein-mediated membrane fusion via large-scale structural rearrangements induced by acidic pH. Here we report the newly determined crystal structure of influenza B virus HA2 in the postfusion state...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1986
ISSN: 0014-5793
DOI: 10.1016/0014-5793(86)80662-7